Respiratory

Leukotriene Receptor Antagonists

Respiratory

Mark this drug class

Examples

montelukast

Prefix / Suffix: -lukast

Physiology

Leukotrienes cause bronchoconstriction, inflammation, and mucus production in the airways. Blocking them helps keep airways open.

Mechanism of Action

They block leukotriene receptors, reducing bronchoconstriction and inflammation.

Indications

  • Asthma maintenance
  • Allergic rhinitis

Side Effects / Adverse Effects

  • Headache
  • Neuropsychiatric effects (mood changes, anxiety, depression)
  • GI upset

Contraindications

  • Acute asthma attack

Nursing Considerations

  • Not for acute attacks (no immediate bronchodilation)
  • Give once daily in the evening (better control of nighttime symptoms)
  • Monitor for mood or behavior changes (important safety warning)
  • Used as add-on therapy, not first-line (for patients not controlled on ICS)

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Disclaimer: PharmPal Nurse is for education only and is not medical advice. Do not use it to diagnose, treat, prescribe, or make patient-care decisions; always verify with current drug references, your instructor, facility policy, and a licensed provider. In emergencies, call local emergency services.