Antidepressants — SNRIs

Psychiatric

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Examples

venlafaxineduloxetinedesvenlafaxine

Prefix / Suffix: No consistent suffix

Physiology

Both serotonin and norepinephrine influence mood, energy, and pain perception.

Mechanism of Action

Inhibit reuptake of both serotonin and norepinephrine, increasing their synaptic availability.

Indications

Major depressive disorder
Generalized anxiety disorder
Neuropathic pain (duloxetine)
Fibromyalgia

Side Effects / Adverse Effects

Nausea, dry mouth
Hypertension (dose-related, especially venlafaxine)
Sexual dysfunction
Insomnia
Sweating
Discontinuation syndrome

Contraindications

Concurrent MAOI use
Uncontrolled hypertension
Narrow-angle glaucoma

Nursing Considerations

Monitor blood pressure regularly (especially venlafaxine)
Takes 4–6 weeks for full effect
Taper slowly to avoid withdrawal symptoms
Monitor for suicidal ideation
Avoid alcohol and other CNS depressants

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Disclaimer: PharmPal Nurse is for education only and is not medical advice. Do not use it to diagnose, treat, prescribe, or make patient-care decisions; always verify with current drug references, your instructor, facility policy, and a licensed provider. In emergencies, call local emergency services.