Prostaglandin Analogs

Gastrointestinal

Mark this drug class

Examples

misoprostol

Prefix / Suffix: -prostol

Physiology

Prostaglandins protect the gastric mucosa by stimulating mucus and bicarbonate production and reducing acid secretion. NSAIDs reduce prostaglandins, increasing ulcer risk.

Mechanism of Action

They mimic prostaglandins, increasing mucus and bicarbonate secretion and decreasing gastric acid production.

Indications

Prevention of NSAID-induced ulcers

Side Effects / Adverse Effects

Diarrhea (most common)
Abdominal cramping
Uterine contractions (can cause miscarriage)

Contraindications

Pregnancy (causes uterine contractions / abortion)

Nursing Considerations

Pregnancy test before starting in women of childbearing age (critical safety issue)
Educate women to use contraception (teratogenic risk)
Take with food (reduces diarrhea)
Monitor for diarrhea and cramping
Used in patients on long-term NSAIDs

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Disclaimer: PharmPal Nurse is for education only and is not medical advice. Do not use it to diagnose, treat, prescribe, or make patient-care decisions; always verify with current drug references, your instructor, facility policy, and a licensed provider. In emergencies, call local emergency services.