Mineralocorticoids

Endocrine & Metabolic

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Examples

fludrocortisone

Prefix / Suffix: -cortisone

Physiology

Aldosterone from the adrenal cortex regulates sodium retention, potassium excretion, and blood volume.

Mechanism of Action

Synthetic aldosterone — promotes sodium and water retention and potassium excretion at the renal tubules.

Indications

Adrenal insufficiency (Addison's disease)
Orthostatic hypotension (off-label)
Salt-wasting congenital adrenal hyperplasia

Side Effects / Adverse Effects

Hypertension
Edema, weight gain
Hypokalemia
Heart failure (volume overload)
Headache

Contraindications

Heart failure
Uncontrolled hypertension
Severe edema

Nursing Considerations

Monitor BP, weight, and edema regularly
Monitor potassium levels (hypokalemia risk)
Encourage potassium-rich foods if levels low
Daily weights — report rapid gain
Often given with hydrocortisone in Addison's disease
Teach signs of fluid overload

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