Statins (Lipid-Lowering Agents)

Cardiovascular

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Examples

atorvastatinsimvastatin

Prefix / Suffix: -statin

Physiology

Cholesterol contributes to plaque formation in arteries. Statins reduce cholesterol production in the liver.

Mechanism of Action

They inhibit HMG-CoA reductase, reducing cholesterol synthesis and lowering LDL levels.

Indications

Hyperlipidemia
Cardiovascular disease prevention

Side Effects / Adverse Effects

Muscle pain (risk of muscle breakdown)
Hepatotoxicity (affects liver function)
Rhabdomyolysis (severe muscle breakdown)

Contraindications

Liver disease
Pregnancy

Nursing Considerations

Monitor liver enzymes (detects hepatotoxicity early)
Assess for muscle pain or weakness (sign of rhabdomyolysis)
Administer in the evening (cholesterol synthesis is higher at night)
Avoid grapefruit juice (increases drug levels → toxicity risk)

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Disclaimer: PharmPal Nurse is for education only and is not medical advice. Do not use it to diagnose, treat, prescribe, or make patient-care decisions; always verify with current drug references, your instructor, facility policy, and a licensed provider. In emergencies, call local emergency services.