Tetracyclines

Anti-Infectives

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Examples

doxycyclinetetracyclineminocycline

Prefix / Suffix: -cycline

Physiology

Bacterial protein synthesis depends on the 30S ribosomal subunit.

Mechanism of Action

They bind the 30S ribosomal subunit, blocking bacterial protein synthesis (bacteriostatic).

Indications

Acne
Lyme disease
Chlamydia
Rickettsial infections
Atypical pneumonia

Side Effects / Adverse Effects

Photosensitivity (severe sunburn)
Tooth discoloration in children
GI upset
Hepatotoxicity
Esophageal irritation

Contraindications

Pregnancy and breastfeeding
Children under 8 years (tooth staining, bone growth issues)

Nursing Considerations

Avoid in pregnancy and children under 8 (tooth/bone effects)
Take with full glass of water and remain upright 30 min (prevents esophageal ulcers)
Avoid dairy, antacids, iron, calcium within 2 hours (chelation reduces absorption)
Use sunscreen and protective clothing (photosensitivity)
Do not use expired tetracyclines (nephrotoxic when degraded)

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Disclaimer: PharmPal Nurse is for education only and is not medical advice. Do not use it to diagnose, treat, prescribe, or make patient-care decisions; always verify with current drug references, your instructor, facility policy, and a licensed provider. In emergencies, call local emergency services.